DSAEK and DMEK are both partial thickness corneal transplants that involve removal and replacement of the inner layer of the cornea. The goal of these surgeries is to replace the damaged endothelial cells that are responsible for pumping fluid out of the cornea. Indications for surgery include Fuchs’ Dystrophy, Aphakic/Pseudophakic bullous keratopathy, or any disease affecting the endothelial cell layer of the cornea. In both of these procedures, the patient’s Descemet’s membrane (the innermost membrane of the cornea) is peeled off and replaced with a partial thickness donor graft containing healthy endothelial cells. In DSAEK the graft is thicker and includes part of the stromal (middle) layer of the cornea as well as the Descemet’s membrane and endothelium. In DMEK the graft is thinner and includes only the Descemet’s membrane and endothelium. An air or gas bubble is then placed in the eye to help hold the graft in place. The surgery usually takes less than an hour. After surgery, it is important to maintain face-up positioning for the first few days. These surgeries are less invasive and the recovery time is much quicker than for a full thickness transplant.